Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

@article{Lash2006MitochondrialGT,
  title={Mitochondrial glutathione transport: physiological, pathological and toxicological implications.},
  author={Lawrence H Lash},
  journal={Chemico-biological interactions},
  year={2006},
  volume={163 1-2},
  pages={54-67}
}
Although most cellular glutathione (GSH) is in the cytoplasm, a distinctly regulated pool is present in mitochondria. Inasmuch as GSH synthesis is primarily restricted to the cytoplasm, the mitochondrial pool must derive from transport of cytoplasmic GSH across the mitochondrial inner membrane. Early studies in liver mitochondria primarily focused on the relationship between GSH status and membrane permeability and energetics. Because GSH is an anion at physiological pH, this suggested that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 84 extracted citations

Similar Papers

Loading similar papers…