Mitochondrial glutathione protects against cell death induced by oxidative and nitrative stress in astrocytes.

@article{Muyderman2007MitochondrialGP,
  title={Mitochondrial glutathione protects against cell death induced by oxidative and nitrative stress in astrocytes.},
  author={H{\aa}kan Muyderman and Alison L Wadey and Michael Nilsson and Neil R Sims},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 4},
  pages={
          1369-82
        }
}
The major cellular antioxidant, glutathione, is mostly localized in the cytosol but a small portion is found in mitochondria. We have recently shown that highly selective depletion of mitochondrial glutathione in astrocytes in culture markedly increased cell death induced by the peroxynitrite donor, 3-morpholino-syndnonimine. The present study was aimed at characterizing the increase in susceptibility arising from mitochondrial glutathione loss and testing the possibility that elevating this… CONTINUE READING
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