Mitochondrial genome variation and the origin of modern humans

@article{Ingman2000MitochondrialGV,
  title={Mitochondrial genome variation and the origin of modern humans},
  author={Max Ingman and Henrik Kaessmann and Svante P{\"a}{\"a}bo and Ulf Gyllensten},
  journal={Nature},
  year={2000},
  volume={408},
  pages={708-713}
}
The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome. These studies are complicated by the extreme variation in substitution rate… CONTINUE READING
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