Mitochondrial genome variation and the origin of modern humans

@article{Ingman2000MitochondrialGV,
  title={Mitochondrial genome variation and the origin of modern humans},
  author={M. Ingman and Henrik Kaessmann and S. P{\"a}{\"a}bo and U. Gyllensten},
  journal={Nature},
  year={2000},
  volume={408},
  pages={708-713}
}
  • M. Ingman, Henrik Kaessmann, +1 author U. Gyllensten
  • Published 2000
  • Biology, Medicine
  • Nature
  • The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome. These studies are complicated by the extreme variation in substitution rate… CONTINUE READING
    1,326 Citations

    Figures, Tables, and Topics from this paper

    Analysis of the complete human mtDNA genome: methodology and inferences for human evolution.
    • 79
    • PDF
    Mutation patterns of mtDNA: Empirical inferences for the coding region
    • 27
    • Highly Influenced
    • PDF
    Mutation and linkage disequilibrium in human mtDNA
    • 88
    • PDF
    Mitochondrial DNA and human evolution.
    • 143
    Maternal ancestry and population history from whole mitochondrial genomes
    • 75
    Distribution of nucleotide substitutions in human mitochondrial DNA genes
    • 5
    • PDF
    Revealing the hidden complexities of mtDNA inheritance
    • 239
    • Highly Influenced
    • PDF
    The Mitochondrial Genome and Human Mitochondrial Diseases
    • 9
    Improved Calibration of the Human Mitochondrial Clock Using Ancient Genomes
    • 66
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 40 REFERENCES
    Age of the common ancestor of human mitochondrial DNA.
    • M. Nei
    • Biology, Medicine
    • Molecular biology and evolution
    • 1992
    • 43
    • PDF
    Rapid evolution of animal mitochondrial DNA.
    • W. Brown, M. George, A. Wilson
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1979
    • 2,657
    • PDF
    Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
    • 552
    • PDF
    Mitochondrial COII sequences and modern human origins.
    • 104
    • PDF
    Genetic Structure of the Ancestral Population of Modern Humans
    • 101
    • PDF
    Maternal inheritance of human mitochondrial DNA.
    • 1,177
    • PDF