Mitochondrial genome variation and the origin of modern humans

  title={Mitochondrial genome variation and the origin of modern humans},
  author={M. Ingman and Henrik Kaessmann and S. P{\"a}{\"a}bo and U. Gyllensten},
  • M. Ingman, Henrik Kaessmann, +1 author U. Gyllensten
  • Published 2000
  • Biology, Medicine
  • Nature
  • The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of inheritance. However, almost all studies of human evolution based on mtDNA sequencing have been confined to the control region, which constitutes less than 7% of the mitochondrial genome. These studies are complicated by the extreme variation in substitution rate… CONTINUE READING
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