Mitochondrial genome mutation in cell death and aging.

  • T. Ozawa
  • Published 1999 in Journal of bioenergetics and biomembranes


This article reviews the concept, molecular genetics, and pathology of cell death and aging in relation to mitochondrial genome mutation. Accumulating evidence emphasizes the role of genetic factors in the development of naturally occurring cell death and aging. The ATP required for a cell's biological activity is almost exclusively produced by mitochondria… (More)


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