Mitochondrial genome evolution and the origin of eukaryotes.

  title={Mitochondrial genome evolution and the origin of eukaryotes.},
  author={Bernd Franz Lang and Michael W. Gray and Gertraud Burger},
  journal={Annual review of genetics},
Recent results from ancestral (minimally derived) protists testify to the tremendous diversity of the mitochondrial genome in various eukaryotic lineages, but also reinforce the view that mitochondria, descendants of an endosymbiotic alpha-Proteobacterium, arose only once in evolution. The serial endosymbiosis theory, currently the most popular hypothesis to explain the origin of mitochondria, postulates the capture of an alpha-proteobacterial endosymbiont by a nucleus-containing eukaryotic… 

Origin of eukaryotes from within archaea, archaeal eukaryome and bursts of gene gain: eukaryogenesis just made easier?

  • E. Koonin
  • Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2015
Comparative genomic analysis clearly shows that the last eukaryotic common ancestor (LECA) possessed most of the signature complex features of modern eUKaryotic cells, in particular the mitochondria, the endomembrane system including the nucleus, an advanced cytoskeleton and the ubiquitin network.

Phylogenomic Reconstruction Indicates Mitochondrial Ancestor Was an Energy Parasite

This reconstruction depicts a more streamlined proto-mitochondrion than these predicted by previous studies, and revealed several novel insights into the mitochondria-derived eukaryotic metabolisms including the lipid metabolism.

The new phylogeny of eukaryotes.

Pochodzenie i ewolucja genomu mitochondrialnego

Current models closely tie the origin of the eukaryotic cell to the endosymbiotic acquisition of mitochondria, that descent from the eubacterial lineage, and the persistence of the mitochondrial genome to the particular biophysical properties of the proteins it encodes.


In recent years a consensus has emerged from molecular phylogenetic investigations favoring a common endosymbiotic ancestor for all chloroplasts. It is within this conceptual framework that most



A New Aspect to the Origin and Evolution of Eukaryotes

This paper suggests, based on the energetic aspect of genome organization, that the emergence of eukaryotes was promoted by the establishment of an efficient energy-converting organelle, such as the mitochondrion, which was acquired by the endosymbiosis of ancient α-purple photosynthetic Gram-negative eubacteria that reorganized the prokaryotic metabolism of the archaebacterial-like ancestral host cells.

An ancestral mitochondrial DNA resembling a eubacterial genome in miniature

Feature of gene content together with eubacterial characteristics of genome organization and expression not found before in mitochondrial genomes indicate that R. americana mtDNA more closely resembles the ancestral proto-mitochondrial genome than any other mtDNA investigated to date.

Reconstructing Early Events in Eukaryotic Evolution

  • A. Roger
  • Biology
    The American Naturalist
  • 1999
Investigation of the nuclear genomes of entamoebae, Microsporidia, parabasalids, and diplomonads suggests that these organisms likely descend from mitochondrion‐bearing ancestors, and most evidence suggests that the mitochondrial endosymbiosis took place prior to the divergence of all extant eukaryotes.

Genome structure and gene content in protist mitochondrial DNAs.

A review of protist mtDNA sequences determined to date comments on such aspects as mitochondrial genome structure, gene content, ribosomal RNA, introns, transfer RNAs and the genetic code and phylogenetic implications, and illustrates the utility of a comparative genomics approach to gene identification.

A Comparative Genomics Approach to the Evolution of Eukaryotes and their Mitochondria 1

Gene repertoire and gene order comparisons as well as multiple‐gene phylogenies support the view of a single endosymbiotic origin of mitochondria, whose closest extant relatives are Rickettsia‐type α‐Proteobacteria.

History assignment: when was the mitochondrion founded?

  • M. Sogin
  • Biology
    Current opinion in genetics & development
  • 1997

The mosaic nature of the eukaryotic nucleus.

The phylogenies for each of the protein-coding genes from the Methanococcus jannaschii genome were surveyed to determine the history of the major groups of life, and results indicate that support for the early history of life is not unequivocal.

The origin of the eukaryotic cell.