Mitochondrial genetics. VII. Allelism and mapping studies of ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin in S. cerevisiae.

@article{Netter1974MitochondrialGV,
  title={Mitochondrial genetics. VII. Allelism and mapping studies of ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin in S. cerevisiae.},
  author={P. Netter and Eric Petrochilo and Piotr P. Slonimski and Monique Bolotin-Fukuhara and Daniele Coen and Joseph Deutsch and Bernard Dujon},
  journal={Genetics},
  year={1974},
  volume={78 4},
  pages={1063-100}
}
We have isolated 15 spontaneous mutants resistant to one or several antibiotics like chloramphenicol, erythromycin and spiramycin. We have shown by several criteria that all of them result from mutations localized in the mitochondrial DNA. The mutations have been mapped by allelism tests and by two- and three-factor crosses involving various configurations of resistant and sensitive alleles associated in cis or in trans with the mitochondrial locus omega which governs the polarity of genetic… CONTINUE READING
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A model for recombination and segregation of mitochonrial genomes in Saccharomyces cereuisiae

  • P. P. SLONIMSKI
  • 1973

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