Mitochondrial gene therapy: an evaluation of strategies for the treatment of mitochondrial DNA disorders.

@article{Doyle2008MitochondrialGT,
  title={Mitochondrial gene therapy: an evaluation of strategies for the treatment of mitochondrial DNA disorders.},
  author={Stephen R. Doyle and Chee Kai Chan},
  journal={Human gene therapy},
  year={2008},
  volume={19 12},
  pages={1335-48}
}
Mitochondrial DNA (mtDNA) disorders include a vast range of pathological conditions, despite each sharing a mutual inability to produce ATP efficiently as a result of defective oxidative phosphorylation. There is no clear consensus regarding an effective therapeutic approach, and consequently the current treatment strategies are largely supportive rather than curative. This is almost certainly the result of there being virtually no defined genotype-phenotype relationships among the mtDNA… CONTINUE READING

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