Mitochondrial gene mutations in the tRNA(Leu(UUR)) region and diabetes: prevalence and clinical phenotypes in Japan.

@article{Ohkubo2001MitochondrialGM,
  title={Mitochondrial gene mutations in the tRNA(Leu(UUR)) region and diabetes: prevalence and clinical phenotypes in Japan.},
  author={Kumiko Ohkubo and Arisa Yamano and Makoto Nagashima and Yoshihisa Mori and Keizo Anzai and Yuko Akehi and Riku Nomiyama and Tsutomu Asano and Akinori Urae and Junko Ono},
  journal={Clinical chemistry},
  year={2001},
  volume={47 9},
  pages={1641-8}
}
BACKGROUND Mitochondrial gene mutations play a role in the development of diabetes mellitus. We have assessed the frequency of the A3243G and other mitochondrial mutations in Japan and in the relationship to clinical features of diabetes. METHODS DNA was obtained from peripheral leukocytes of 240 patients with diabetes mellitus (39 with type 1; 188 with type 2; 13 with gestational diabetes) and 125 control subjects. We used PCR-restriction fragment length polymorphism analysis (ApaI) for… CONTINUE READING