Mitochondrial function in normal and diabetic beta-cells.

  title={Mitochondrial function in normal and diabetic beta-cells.},
  author={Pierre Maechler and Claes B Wollheim},
  volume={414 6865},
The aetiology of type 2, or non-insulin-dependent, diabetes mellitus has been characterized in only a limited number of cases. Among these, mitochondrial diabetes, a rare subform of the disease, is the consequence of pancreatic beta-cell dysfunction caused by mutations in mitochondrial DNA, which is distinct from the nuclear genome. The impact of such mutations on beta-cell function reflects the importance of mitochondria in the control of insulin secretion. The beta-cell mitochondria serve as… CONTINUE READING
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