Mitochondrial function and neurotoxicity.

  title={Mitochondrial function and neurotoxicity.},
  author={Anthony H V Schapira},
  journal={Current opinion in neurology},
  volume={7 6},
There have been important advances in our understanding of the nuclear factors that regulate mitochondrial DNA function. Nuclear involvement in respiratory chain dysfunction is also being investigated, and evidence is accumulating that this may be more important than previously thought. In particular, the cytochrome oxidase deficiency found in senescent tissue may be caused by a nuclear rather than a mitochondrial defect. Studies continue to demonstrate a mitochondrial defect in certain… CONTINUE READING