Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases.

@article{Gu1998MitochondrialFG,
  title={Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases.},
  author={Mei Gu and A. D. Owen and Samuel E Toffa and Jacqueline Cooper and David T Dexter and Peter J. Jenner and C. David Marsden and Anthony H V Schapira},
  journal={Journal of the neurological sciences},
  year={1998},
  volume={158 1},
  pages={24-9}
}
The cause of neuronal loss in patients with idiopathic Parkinson's disease is unknown. Oxidative stress and complex I deficiency have both been identified in the substantia nigra in Parkinson's disease but their place in the sequence of events resulting in dopaminergic cell death is uncertain. We have analysed respiratory chain activity, iron and reduced glutathione concentrations in Parkinson's disease substantia innominata and in the cingulate cortex of patients with Parkinson's disease… CONTINUE READING