Mitochondrial free [Ca2+] levels and the permeability transition.

Abstract

Mitochondrial Ca(2+) activates many processes, from mitochondrial metabolism to opening of the permeability transition pore (PTP) and apoptosis. However, there is considerable controversy regarding the free mitochondrial [Ca(2+)] ([Ca(2+)](M)) levels that can be attained during cell activation or even in mitochondrial preparations. Studies using fluorescent… (More)
DOI: 10.1016/j.ceca.2008.10.007

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