Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence.

  title={Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence.},
  author={Hiromichi Hara and Jun Araya and Saburo Ito and Kenji Kobayashi and Naoki Takasaka and Yutaka Yoshii and Hiroshi Wakui and Jun Kojima and Kenichiro Shimizu and Takanori Numata and Makoto Kawaishi and Noriki Kamiya and Makoto Odaka and Toshiaki Morikawa and Yumi Kaneko and Katsutoshi Nakayama and Kazuyoshi Kuwano},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={305 10},
Mitochondria are dynamic organelles that continuously change their shape through fission and fusion. Disruption of mitochondrial dynamics is involved in disease pathology through excessive reactive oxygen species (ROS) production. Accelerated cellular senescence resulting from cigarette smoke exposure with excessive ROS production has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Hence, we investigated the involvement of mitochondrial dynamics and ROS… 

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