Mitochondrial flashes regulate ATP homeostasis in the heart

@inproceedings{Wang2017MitochondrialFR,
  title={Mitochondrial flashes regulate ATP homeostasis in the heart},
  author={Xianhua Wang and Xing Zhang and Di Wu and Zhanglong Huang and Tingting Hou and Chongshu Jian and Peng Yu and Fujian Lu and Rufeng Zhang and Tao Sun and Jinghang Li and Wenfeng Qi and Yanru Wang and Feng Gao and Heping Cheng},
  booktitle={eLife},
  year={2017}
}
The maintenance of a constant ATP level ('set-point') is a vital homeostatic function shared by eukaryotic cells. In particular, mammalian myocardium exquisitely safeguards its ATP set-point despite 10-fold fluctuations in cardiac workload. However, the exact mechanisms underlying this regulation of ATP homeostasis remain elusive. Here we show mitochondrial flashes (mitoflashes), recently discovered dynamic activity of mitochondria, play an essential role for the auto-regulation of ATP set… CONTINUE READING
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