Mitochondrial fission is an acute and adaptive response in injured motor neurons

@inproceedings{KiryuSeo2016MitochondrialFI,
  title={Mitochondrial fission is an acute and adaptive response in injured motor neurons},
  author={Sumiko Kiryu-Seo and Hiromi Tamada and Yukina Kato and Katsura Yasuda and Naotada Ishihara and Masatoshi Nomura and Katsuyoshi Mihara and Hiroshi Kiyama},
  booktitle={Scientific reports},
  year={2016}
}
Successful recovery from neuronal damage requires a huge energy supply, which is provided by mitochondria. However, the physiological relevance of mitochondrial dynamics in damaged neurons in vivo is poorly understood. To address this issue, we established unique bacterial artificial chromosome transgenic (BAC Tg) mice, which develop and function normally, but in which neuronal injury induces labelling of mitochondria with green fluorescent protein (GFP) and expression of cre recombinase. GFP… CONTINUE READING