Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1–miR-593-5p–MFF axis

@article{Fan2015MitochondrialFD,
  title={Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1–miR-593-5p–MFF axis},
  author={S. Fan and Bodu Liu and Li-juan Sun and Xiaobin Lv and Zhao-yu Lin and Weixiong Chen and Weiliang Chen and Q. Tang and Youyuan Wang and Yuxiong Su and Shaowen Jin and Da-ming Zhang and Jiang-long Zhong and Yilin Li and B. Wen and Z. Zhang and Pu Yang and Bin Zhou and Qixiang Liang and Xing Yu and Yinghua Zhu and Pengnan Hu and Junjun Chu and W. Huang and Y. Feng and H. Peng and Qihong Huang and E. Song and Jinsong Li},
  journal={Oncotarget},
  year={2015},
  volume={6},
  pages={14885 - 14904}
}
Cisplatin has been widely employed as a cornerstone chemotherapy treatment for a wide spectrum of solid neoplasms; increasing tumor responsiveness to cisplatin has been a topic of interest for the past 30 years. Strong evidence has indicated that mitochondrial fission participates in the regulation of apoptosis in many diseases; however, whether mitochondrial fission regulates cisplatin sensitivity remains poorly understood. Here, we show that MFF mediated mitochondrial fission and apoptosis in… Expand
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lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter
  • Song Fan, Tian Tian, +28 authors Jinsong Li
  • Medicine, Chemistry
  • iScience
  • 2020
TLDR
The potential of CISAL-BRCA1 signaling as a potential target to predict or improve chemosensitivity is uncovered and a new model where lncRNAs are tethered at gene promoter by RNA-DNA triplex formation, spatially sequestering transcription factors away from DNA-binding sites is proposed. Expand
The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma
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The importance of the miR-372-ZBTB7A-TRAIL-R2 axis in mediating OSCC pathogenesis and in controlling OSCC drug resistance is indicated and promising strategies for enhancing the sensitivity of OSCC to cisplatin therapy are proposed. Expand
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