Mitochondrial fission and remodelling contributes to muscle atrophy.

@article{Romanello2010MitochondrialFA,
  title={Mitochondrial fission and remodelling contributes to muscle atrophy.},
  author={Vanina Romanello and Eleonora Guadagnin and L{\'i}gia Rebelo Gomes and Ira Roder and Claudia Sandri and Yvonne Petersen and Giulia Milan and Eva Masiero and P. Del Piccolo and Marc Foretz and Luca Scorrano and R{\"u}diger Rudolf and Marco Sandri},
  journal={The EMBO journal},
  year={2010},
  volume={29 10},
  pages={1774-85}
}
Mitochondria are crucial organelles in the production of energy and in the control of signalling cascades. A machinery of pro-fusion and fission proteins regulates their morphology and subcellular localization. In muscle this results in an orderly pattern of intermyofibrillar and subsarcolemmal mitochondria. Muscular atrophy is a genetically controlled process involving the activation of the autophagy-lysosome and the ubiquitin-proteasome systems. Whether and how the mitochondria are involved… CONTINUE READING
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