Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia.

@article{Campanella2009MitochondrialFL,
  title={Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia.},
  author={Alessandro Campanella and Elisabetta Rovelli and Paolo Santambrogio and A. D. Cozzi and Franco Taroni and Sonia Levi},
  journal={Human molecular genetics},
  year={2009},
  volume={18 1},
  pages={1-11}
}
Mitochondrial ferritin (FtMt) is a nuclear-encoded iron-sequestering protein that specifically localizes in mitochondria. In mice it is highly expressed in cells characterized by high-energy consumption, while is undetectable in iron storage tissues like liver and spleen. FtMt expression in mammalian cells was shown to cause a shift of iron from cytosol to mitochondria, and in yeast it rescued the defects associated with frataxin deficiency. To study the role of FtMt in oxidative damage, we… CONTINUE READING
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