Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei.

@article{Guler2008MitochondrialFA,
  title={Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei.},
  author={Jennifer L Guler and Eva Kriegova and Terry K. Smith and Julius Luke{\vs} and Paul T. Englund},
  journal={Molecular microbiology},
  year={2008},
  volume={67 5},
  pages={1125-42}
}
Trypanosoma brucei use microsomal elongases for de novo synthesis of most of its fatty acids. In addition, this parasite utilizes an essential mitochondrial type II synthase for production of octanoate (a lipoic acid precursor) as well as longer fatty acids such as palmitate. Evidence from other organisms suggests that mitochondrially synthesized fatty acids are required for efficient respiration but the exact relationship remains unclear. In procyclic form trypanosomes, we also found that RNAi… CONTINUE READING

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