Mitochondrial fatty acid synthesis and respiration.

@article{Hiltunen2010MitochondrialFA,
  title={Mitochondrial fatty acid synthesis and respiration.},
  author={J Kalervo Hiltunen and Kaija J. Autio and Melissa S Schonauer and V. A. Samuli Kursu and Carol Dieckmann and Alexander J Kastaniotis},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1797 6-7},
  pages={1195-202}
}
Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles bacterial fatty acid synthesis (FAS) type II, which uses discrete, nuclearly encoded proteins. Experimental evidence, obtained mainly through using yeast as a model system, indicates that this pathway is essential for mitochondrial respiratory function. Curiously, the deficiency in mitochondrial FAS cannot be complemented by… CONTINUE READING

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