Mitochondrial expression of the two-pore domain TASK-3 channels in malignantly transformed and non-malignant human cells

@article{Rusznk2007MitochondrialEO,
  title={Mitochondrial expression of the two-pore domain TASK-3 channels in malignantly transformed and non-malignant human cells},
  author={Zolt{\'a}n Ruszn{\'a}k and G{\'a}bor Bakondi and L{\'i}via Kosztka and Krisztina Pocsai and Beatrix Dienes and J{\'a}nos Istv{\'a}n Fodor and Andrea Telek and M{\'o}nika G{\"o}nczi and G{\'e}za Szűcs and L{\'a}szl{\'o} Csernoch},
  journal={Virchows Archiv},
  year={2007},
  volume={452},
  pages={415-426}
}
The presence of TASK-3 channels has been described in a number of healthy and malignantly transformed cells, showing mainly intracellular distribution with relatively insignificant labelling of the cell surface membrane. In this work, immunochemical and molecular biology methods were utilised to establish the intracellular organelle whose TASK-3 expression accounts for this strong intracellular labelling using cultured melanoma and HaCaT cells. Before the immunocytochemical experiments, the… CONTINUE READING

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