Mitochondrial expression and functional activity of breast cancer resistance protein in different multiple drug-resistant cell lines.

@article{Solazzo2009MitochondrialEA,
  title={Mitochondrial expression and functional activity of breast cancer resistance protein in different multiple drug-resistant cell lines.},
  author={Michela Solazzo and Ornella Fantappi{\'e} and Massimo D'Amico and Chiara Sassoli and A. Meziane Tani and Greta Cipriani and Costanza Bogani and Lucia Formigli and Roberto Mazzanti},
  journal={Cancer research},
  year={2009},
  volume={69 18},
  pages={7235-42}
}
The multidrug resistance (MDR) phenotype is characterized by the overexpression of a few transport proteins at the plasma membrane level, one of which is the breast cancer resistance protein (BCRP). These proteins are expressed in excretory organs, in the placenta and blood-brain barrier, and are involved in the transport of drugs and endogenous compounds. Because some of these proteins are expressed in the mitochondria, this study was designed to determine whether BCRP is expressed at a… CONTINUE READING

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