Mitochondrial energetics and therapeutics.

  title={Mitochondrial energetics and therapeutics.},
  author={Douglas C. Wallace and Weiwei Fan and Vincent Procaccio},
  journal={Annual review of pathology},
Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic diseases, cancer, and aging. All these clinical manifestations arise from the central role of bioenergetics in cell biology. Although genetic therapies are maturing as the rules of bioenergetic genetics are clarified, metabolic therapies have been ineffectual. This failure results from our limited appreciation of the role of bioenergetics as the interface between the environment and the cell. A systems… 

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