Mitochondrial endogenous oxidative damage has been overestimated

@article{Anson2000MitochondrialEO,
  title={Mitochondrial endogenous oxidative damage has been overestimated},
  author={R. Michael Anson and E. Hudson and V. Bohr},
  journal={The FASEB Journal},
  year={2000},
  volume={14},
  pages={355 - 360}
}
The oxidatively induced DNA lesion 8‐oxo‐dG in mitochondrial DNA (mtDNA) is commonly used as a marker for oxidative damage to mitochondria, which in turn is thought to be a fundamental cause of aging. For years, mitochondrial levels of 8‐oxo‐dG were believed to be ~10‐fold higher in mtDNA than in nuclear DNA even in normal, young animals. However, studies in our own and other laboratories have shown that this lesion is efficiently repaired. Also, mutational consequences specific to 8‐oxo‐dG (G… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Endogenous oxidative damage of mtDNA.
Oxidative damage to mitochondrial DNA and its relationship to ageing.
  • C. Richter
  • Biology, Medicine
  • The international journal of biochemistry & cell biology
  • 1995
Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
  • C. Richter, J. Park, B. Ames
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria*
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
Quantification of oxidative DNA modifications in mitochondria.
Detection and quantification of oxidative adducts of mitochondrial DNA.
...
1
2
3
...