Mitochondrial endogenous oxidative damage has been overestimated

@article{MichaelAnson2000MitochondrialEO,
  title={Mitochondrial endogenous oxidative damage has been overestimated},
  author={Robert Michael Anson and Edgar K. Hudson and Vilhelm A. Bohr},
  journal={The FASEB Journal},
  year={2000},
  volume={14},
  pages={355 - 360}
}
The oxidatively induced DNA lesion 8‐oxo‐dG in mitochondrial DNA (mtDNA) is commonly used as a marker for oxidative damage to mitochondria, which in turn is thought to be a fundamental cause of aging. For years, mitochondrial levels of 8‐oxo‐dG were believed to be ~10‐fold higher in mtDNA than in nuclear DNA even in normal, young animals. However, studies in our own and other laboratories have shown that this lesion is efficiently repaired. Also, mutational consequences specific to 8‐oxo‐dG (G… 

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