Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production.

@article{ReyesOcampo2015MitochondrialDR,
  title={Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production.},
  author={Jazmin Gabriela Reyes-Ocampo and Daniela Ram{\'i}rez-Ortega and G I V{\'a}zquez Cervantes and Benjam{\'i}n Pineda and Pavel Montes de Oca Balderas and Dinora Gonz{\'a}lez-Esquivel and Laura S{\'a}nchez-Chapul and Rafael Lugo-Huitr{\'o}n and D Silva-Adaya and Camilo R{\'i}os and Anabel Jim{\'e}nez-Anguiano and Ver{\'o}nica P{\'e}rez-de la Cruz},
  journal={Neurotoxicology},
  year={2015},
  volume={50},
  pages={81-91}
}
The kynurenines 3-hydroxyanthranilic acid (3-HANA) and its precursor 3-hydroxykynurenine (3-HK) are metabolites derived from tryptophan degradation. 3-HK, has been related to diverse neurodegenerative diseases including Huntington's, Alzheimer's and Parkinson's diseases that share mitochondrial metabolic dysregulation. Nevertheless, the direct effect of these kynurenines on mitochondrial function has not been investigated despite it could be regulated by their redox properties that are… CONTINUE READING
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