Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes.

@article{ValcrcelAres2014MitochondrialDP,
  title={Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes.},
  author={Marta N Valc{\'a}rcel-Ares and Romina R Riveiro-Naveira and Carlos Vaamonde-Garc{\'i}a and J Rodrigues Loureiro and Laura Hermida-Carballo and Francisco J Blanco and Mar{\'i}a J L{\'o}pez-Armada},
  journal={Rheumatology},
  year={2014},
  volume={53 7},
  pages={1332-43}
}
OBJECTIVES In RA, synoviocytes cause increased oxidative stress, leading to mitochondrial alterations that may participate in the pathogenesis of RA. Here we investigated whether mitochondrial dysfunction induces inflammatory responses in cultured normal human synoviocytes, a hallmark of RA. METHODS Mitochondrial dysfunction was induced with the inhibitor oligomycin. The effects of mitochondrial dysfunction on cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) and IL-8 expression; cellular and… CONTINUE READING
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