Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice.

@article{Sun2007MitochondrialDP,
  title={Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice.},
  author={Kaihua Sun and Brian S Johnson and Teresa M. Gunn},
  journal={Neurobiology of aging},
  year={2007},
  volume={28 12},
  pages={1840-52}
}
Oxidative stress, ubiquitination defects and mitochondrial dysfunction are commonly associated with neurodegeneration. Mice lacking mahogunin ring finger-1 (MGRN1) or attractin (ATRN) develop age-dependent spongiform neurodegeneration through an unknown mechanism. It has been suggested that they act in a common pathway. As MGRN1 is an E3 ubiquitin ligase, proteomic analysis of Mgrn1 mutant and control brains was performed to explore the hypothesis that loss of MGRN1 causes neurodegeneration via… CONTINUE READING