Mitochondrial dysfunction of a cultured Chinese hamster ovary cell mutant deficient in cardiolipin.

@article{Ohtsuka1993MitochondrialDO,
  title={Mitochondrial dysfunction of a cultured Chinese hamster ovary cell mutant deficient in cardiolipin.},
  author={Teruya Ohtsuka and Masahiro Nishijima and Kazuo Suzuki and Yuzuru Akamatsu},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 30},
  pages={22914-9}
}
In our preceding paper, we reported that a temperature-sensitive Chinese hamster ovary cell mutant, PGS-S, with thermolabile phosphatidylglycerophosphate synthase was defective in the biogenesis of both phosphatidylglycerol and cardiolipin (CL) at a nonpermissive temperature (Ohtsuka, T., Nishijima, M., and Akamatsu, Y. (1993) J. Biol. Chem. 268, 22908-22913). To investigate the biological role of cardiolipin, we examined the structure and function of mitochondria in mutant PGS-S cells, since… CONTINUE READING

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