Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin.

@article{Waseem2013MitochondrialDM,
  title={Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin.},
  author={Mohammad Waseem and Suhel Parvez},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={53},
  pages={334-42}
}
Anticancer agents help to suppress cellular damage but subsequently can lead to side effects and toxic manifestations. Toxicity of anticancer drug cisplatin (CP) is attributed to its interference of biological enzymes in metabolic pathways. Mitochondria have been recognized as targets in various kinds of toxicity including neurotoxicity and hepatotoxicity that can lead to neoplastic disease. Curcumin (CMN) is a known cytoprotectant with comprehensive anti-inflammatory and anti-cancerous… CONTINUE READING
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