Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes

@article{Gao2010MitochondrialDI,
  title={Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes},
  author={Chun-lin Gao and Chun Shan Zhu and Ya-ping Zhao and Xiao-hui Chen and Xi-rong Guo},
  journal={Molecular and Cellular Endocrinology},
  year={2010},
  volume={320},
  pages={25-33}
}
Hyperglycemia and high free fatty acids (FFAs) are two well-known characteristics of type 2 diabetes, and are also implicated in the etiology of insulin resistance. However, their roles in mitochondrial dysfunction of white adipocytes are not well-studied. In this study, we investigated the effects of high glucose (25 mM), high free fatty acids (FFAs, 1mM), or a combination of both high glucose+high FFAs on mitochondrial function in differentiated 3T3-L1 adipocytes after 48 h of treatment. We… CONTINUE READING
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