Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder with unknown etiology. It is marked by widespread neurodegeneration in the brain with profound loss of A9 midbrain dopaminergic neurons in substantia nigra pars compacta. Several theories of biochemical abnormalities have been linked to pathogenesis of PD of which mitochondrial… (More)
DOI: 10.1016/j.bbadis.2008.11.007

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