Mitochondrial dysfunction in reproduction.

@article{Jansen2004MitochondrialDI,
  title={Mitochondrial dysfunction in reproduction.},
  author={Robert P S Jansen and Graham J Burton},
  journal={Mitochondrion},
  year={2004},
  volume={4 5-6},
  pages={577-600}
}
The mitochondrial genome passes from one generation to the next by way of the egg's cytoplasm, so ordinarily an individual's mitochondrial DNA (mtDNA) is entirely derived from his or her mother. A potential mother has a finite number of eggs, or oocytes, all of which were formed when she herself was still a fetus, many years before she can conceive. The eggs are progressively depleted through childhood and her reproductive years at a much faster rate than is accounted for by ovulation. Up to a… CONTINUE READING

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