Mitochondrial dysfunction in neurodegenerative disorders.

  title={Mitochondrial dysfunction in neurodegenerative disorders.},
  author={Martin Baron and A. P. Kudin and Wolfram S Kunz},
  journal={Biochemical Society transactions},
  volume={35 Pt 5},
There is compelling evidence for the direct involvement of mitochondria in certain neurodegenerative disorders, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis), and temporal lobe epilepsy with Ammon's horn sclerosis. This evidence includes the direct genetic evidence of pathogenic mutations in mitochondrial proteins in inherited Parkinsonism {such as PARK6, with mutations in the mitochondrial PINK1 [PTEN (phosphatase and tensin homologue deleted on… CONTINUE READING
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