Mitochondrial dysfunction in hearing loss.

  title={Mitochondrial dysfunction in hearing loss.},
  author={Nathan Fischel-Ghodsian and Richard D. Kopke and Xianxi Ge},
  volume={4 5-6},
Mitochondrial pathology plays an important role in both inherited and acquired hearing loss. Inherited mitochondrial DNA mutations have been implicated in both syndromic and non-syndromic hearing loss, as well as in predisposition to aminoglycoside ototoxicity. Acquired mitochondrial dysfunction in the absence of mitochondrial DNA mutations has also been proposed as playing an important role in noise-induced and toxin-induced hearing loss. Presbycusis, the hearing loss associated with aging… CONTINUE READING


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