Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy.

@article{Lehmann2011MitochondrialDI,
  title={Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy.},
  author={Helmar Christoph Lehmann and Weiran Chen and Jasenka Borzan and Joseph L Mankowski and Ahmet H{\"o}ke},
  journal={Annals of neurology},
  year={2011},
  volume={69 1},
  pages={100-10}
}
OBJECTIVE Accumulation of mitochondrial DNA (mtDNA) damage has been associated with aging and abnormal oxidative metabolism. We hypothesized that in human immunodeficiency virus-associated sensory neuropathy (HIV-SN), damaged mtDNA accumulates in distal nerve segments, and that a spatial pattern of mitochondrial dysfunction contributes to the distal degeneration of sensory nerve fibers. METHODS We measured levels of common deletion mutations in mtDNA and expression levels of mitochondrial… CONTINUE READING
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