Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication.

@article{Shapovalov2011MitochondrialDI,
  title={Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication.},
  author={Yuriy Shapovalov and David D. Hoffman and Daniel Zuch and Karen L. De Mesy Bentley and Roman A Eliseev},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 25},
  pages={22331-8}
}
Warburg effect is a hallmark of cancer manifested by continuous prevalence of glycolysis and dysregulation of oxidative metabolism. Glycolysis provides survival advantage to cancer cells. To investigate molecular mechanisms underlying the Warburg effect, we first compared oxygen consumption among hFOB osteoblasts, benign osteosarcoma cells, Saos2, and aggressive osteosarcoma cells, 143B. We demonstrate that, as both proliferation and invasiveness increase in osteosarcoma, cells utilize… CONTINUE READING
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