Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives

  title={Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives},
  author={F. Hollis and Alexandros K Kanellopoulos and C. Bagni},
  journal={Current Opinion in Neurobiology},
  • F. Hollis, Alexandros K Kanellopoulos, C. Bagni
  • Published 2017
  • Psychology, Medicine
  • Current Opinion in Neurobiology
  • Autism Spectrum Disorder (ASD) is a prototypic pervasive developmental disorder characterized by social interaction, and communication deficits, repetitive, stereotypic patterns of behavior, and impairments in language and development. Clinical studies have identified mitochondrial disturbances at the levels of DNA, activity, complexes, oxidative stress, and metabolites in blood and urine of ASD patients. However, these observations from postmortem brains or peripheral tissues do not provide a… CONTINUE READING
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