Mitochondrial dysfunction in Alzheimer’s disease - a proteomics perspective

  title={Mitochondrial dysfunction in Alzheimer’s disease - a proteomics perspective},
  author={Morteza Abyadeh and Vivek K. Gupta and Nitin Chitranshi and Veer Bala Gupta and Yunqi Wu and Danit Saks and Roshana Wander Wall and Matthew J. Fitzhenry and D. Basavarajappa and Y. You and G. Salekdeh and P. Haynes and S. Graham and M. Mirzaei},
  journal={Expert Review of Proteomics},
  pages={295 - 304}
ABSTRACT Mitochondrial dysfunction is involved in Alzheimer’s disease (AD) pathogenesis. Mitochondria have their own genetic material; however, most of their proteins (∼99%) are synthesized as precursors on cytosolic ribosomes, and then imported into the mitochondria. Therefore, exploring proteome changes in these organelles can yield valuable information and shed light on the molecular mechanisms underlying mitochondrial dysfunction in AD. Here, we review AD-associated mitochondrial changes… Expand
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