Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

@article{Pongratz2009MitochondrialDC,
  title={Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.},
  author={Rebecca L. Pongratz and Richard Glenn Kibbey and Clare L. Kirkpatrick and Xiaojian Zhao and Marco Pontoglio and M. Yaniv and Claes B Wollheim and Gerald I Shulman and Gary W. Cline},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 25},
  pages={16808-21}
}
Maturity Onset Diabetes of the Young-type 3 (MODY-3) has been linked to mutations in the transcription factor hepatic nuclear factor (HNF)-1alpha, resulting in deficiency in glucose-stimulated insulin secretion. In INS-1 cells overexpressing doxycycline-inducible HNF-1alpha dominant-negative (DN-) gene mutations, and islets from Hnf-1alpha knock-out mice, insulin secretion was impaired in response to glucose (15 mm) and other nutrient secretagogues. Decreased rates of insulin secretion in… CONTINUE READING
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Mitochondrial Defects of HNF-1 Mutation in INS-1 Cells

  • F. Schuit, A. De Vos, +4 authors M. Prentki
  • J. Biol. Chem
  • 1997

Biological Application of Magnetic Resonance (Shulman

  • D. G. Gadian, G. K. Radda, R. E. Richards, P. J. Seeley
  • R. G.,
  • 1979

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