Mitochondrial dysfunction contributes to oncogene-induced senescence.

@article{Moiseeva2009MitochondrialDC,
  title={Mitochondrial dysfunction contributes to oncogene-induced senescence.},
  author={Olga A. Moiseeva and V{\'e}ronique Bourdeau and Antoine Roux and Xavier Desch{\^e}nes-Simard and Gerardo Ferbeyre},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 16},
  pages={
          4495-507
        }
}
The expression of oncogenic ras in normal human cells quickly induces an aberrant proliferation response that later is curtailed by a cell cycle arrest known as cellular senescence. Here, we show that cells expressing oncogenic ras display an increase in the mitochondrial mass, the mitochondrial DNA, and the mitochondrial production of reactive oxygen species (ROS) prior to the senescent cell cycle arrest. By the time the cells entered senescence, dysfunctional mitochondria accumulated around… CONTINUE READING

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