Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients.

@article{Dutta2006MitochondrialDA,
  title={Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients.},
  author={Ranjan Dutta and Jennifer McDonough and Xinghua Yin and John Peterson and Ansi Chang and Thalia Torres and Tatyana I. Gudz and Wendy B Macklin and David A. Lewis and R J Fox and Richard A. Rudick and Karoly Mirnics and Bruce D Trapp},
  journal={Annals of neurology},
  year={2006},
  volume={59 3},
  pages={478-89}
}
OBJECTIVE Degeneration of chronically demyelinated axons is a major cause of irreversible neurological disability in multiple sclerosis (MS) patients. Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate. METHODS We report ultrastructural changes that support Ca2+-mediated… CONTINUE READING