Mitochondrial dysfunction as a cause of ageing.

  title={Mitochondrial dysfunction as a cause of ageing.},
  author={Aleksandra Trifunovic and N-G Larsson},
  journal={Journal of internal medicine},
  volume={263 2},
Mitochondrial dysfunction is heavily implicated in the ageing process. Increasing age in mammals correlates with accumulation of somatic mitochondrial DNA (mtDNA) mutations and decline in respiratory chain function. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. Studies of mtDNA mutator mice has shown that increased levels of somatic mtDNA… CONTINUE READING


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