Mitochondrial dysfunction as a cause of ageing

@article{Trifunovic2008MitochondrialDA,
  title={Mitochondrial dysfunction as a cause of ageing},
  author={Aleksandra Trifunovic and Nils-G{\"o}ran Larsson},
  journal={Journal of Internal Medicine},
  year={2008},
  volume={263}
}
Mitochondrial dysfunction is heavily implicated in the ageing process. Increasing age in mammals correlates with accumulation of somatic mitochondrial DNA (mtDNA) mutations and decline in respiratory chain function. The age‐associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. Studies of mtDNA mutator mice has shown that increased levels of somatic mtDNA… Expand
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From DEPARTMENT OF LABORATORY MEDICINE Karolinska Institutet, Stockholm, Sweden MOLECULAR MECHANISMS OF AGING IN MTDNA MUTATOR MICE
Mitochondria are intensely studied in the field of aging. mtDNA mutator mice have a proofreading deficiency in the mitochondrial DNA polymerase POLG, which causes a large amount of point mutations toExpand
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