Mitochondrial dysfunction and transactivation of p53-dependent apoptotic genes in BaP-treated human fetal lung fibroblasts.

@article{Yang2011MitochondrialDA,
  title={Mitochondrial dysfunction and transactivation of p53-dependent apoptotic genes in BaP-treated human fetal lung fibroblasts.},
  author={Guangtao Yang and Ying Jiang and K Sudhindra Rao and Xi Chen and Qian Wang and Ai-lin Liu and Wei Xiong and Jing Yuan},
  journal={Human & experimental toxicology},
  year={2011},
  volume={30 12},
  pages={1904-13}
}
Benzo(a)pyrene (BaP) has been shown to be an inducer of apoptosis. However, mechanisms involved in BaP-induced mitochondrial dysfunction are not well-known. In this study, human fetal lung fibroblasts cells were treated with BaP (8, 16, 32, 64 and 128 μM) for 4 and 12 h. Cell viability, intracellular level of reactive oxygen species (ROS), total antioxidant… CONTINUE READING