Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia.

@article{Clay2011MitochondrialDA,
  title={Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia.},
  author={Hayley B. Clay and Stephanie E. Sillivan and Christine Konradi},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year={2011},
  volume={29 3},
  pages={311-24}
}
Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in these disorders. Several pieces of evidence point to an underlying dysfunction of mitochondria: (i) decreased mitochondrial respiration; (ii) changes in mitochondrial morphology; (iii) increases in mitochondrial DNA (mtDNA) polymorphisms and in levels of mtDNA mutations; (iv) downregulation of nuclear mRNA molecules and… CONTINUE READING
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