Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

@inproceedings{Wu2009MitochondrialDA,
  title={Mitochondrial dysfunction and oxidative stress mediate the physiological impairment
                        induced by the disruption of autophagy},
  author={Jian Wu and Celia Quijano and Edmund I-Tsuen Chen and Hongjun Liu and Liu Cao and Maria M. Fergusson and I. Rovira and Sarah Gutkind and Mathew P. Daniels and M. Asaliaru Komatsu and Toren Finkel},
  booktitle={Aging},
  year={2009}
}
Impaired or deficient autophagy is believed to cause or contribute to aging, as well as a number of age-related pathologies. The exact mechanism through which alterations in autophagy induce these various pathologies is not well understood. Here we describe the creation of two in vivo mouse models that allow for the characterization of the alteration in mitochondrial function and the contribution of the corresponding oxidative stress following deletion of Atg7. Using these models we demonstrate… CONTINUE READING
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