Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

  title={Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases},
  author={Michael T. Lin and M. Flint Beal},
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases. In all major examples of these diseases there is strong evidence that mitochondrial dysfunction occurs early and acts causally in disease pathogenesis… 
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