Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism.

@article{Hauser2013MitochondrialDA,
  title={Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism.},
  author={David N. Hauser and Teresa G Hastings},
  journal={Neurobiology of disease},
  year={2013},
  volume={51},
  pages={35-42}
}
The pathogenic mechanisms that underlie Parkinson's disease remain unknown. Here, we review evidence from both sporadic and genetic forms of Parkinson's disease that implicate both mitochondria and oxidative stress as central players in disease pathogenesis. A systemic deficiency in complex I of the mitochondrial electron transport chain is evident in many patients with the disease. Oxidative stress caused by reactive metabolites of dopamine and alterations in the levels of iron and glutathione… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
101 Citations
136 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 101 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 136 references

Similar Papers

Loading similar papers…