Mitochondrial dysfunction and molecular pathways of disease.

@article{Pieczenik2007MitochondrialDA,
  title={Mitochondrial dysfunction and molecular pathways of disease.},
  author={Steve R Pieczenik and John Neustadt},
  journal={Experimental and molecular pathology},
  year={2007},
  volume={83 1},
  pages={
          84-92
        }
}
Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health, disease, and aging. A wide range of seemingly unrelated disorders, such as schizophrenia, bipolar disease, dementia, Alzheimer's disease, epilepsy, migraine headaches, strokes, neuropathic pain, Parkinson's disease, ataxia, transient ischemic attack, cardiomyopathy, coronary artery disease, chronic fatigue syndrome, fibromyalgia, retinitis… Expand
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References

SHOWING 1-10 OF 96 REFERENCES
Neuronal degeneration and mitochondrial dysfunction.
Over the last decade, the underlying genetic bases of several neurodegenerative disorders, including Huntington disease (HD), Friedreich ataxia, hereditary spastic paraplegia, and rare familial formsExpand
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
  • D. Wallace
  • Biology, Medicine
  • Annual review of genetics
  • 2005
TLDR
The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today. Expand
Mitochondrial dysfunction in bipolar disorder.
TLDR
The mitochondrial dysfunction hypothesis, which comprehensively accounts for the pathophysiology of bipolar disorder, is proposed and it is found that 5178C and 10398A polymorphisms in mtDNA were risk factors for bipolar disorder. Expand
Review of the literature on major mental disorders in adult patients with mitochondrial diseases.
TLDR
The authors retrieved 19 case reports that describe patients with mitochondrial diseases and psychiatric disorders and argued that mitochondrial dysfunction is related to the pathophysiology of bipolar disorder and schizophrenia. Expand
Mitochondrial Dysfunction as an Initiating Event in Atherogenesis: A Plausible Hypothesis
TLDR
It is proposed that mitochondrial dysfunction, besides endothelial dysfunction, represents an important early step in the chain of events leading to atherosclerotic disease. Expand
Parkinson's Disease Mechanisms and Models
TLDR
PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process. Expand
How Mitochondrial Damage Affects Cell Function
TLDR
How the accumulation of mtDNA mutations can lead to cell dysfunction by altering oxidative phosphorylation, Ca2+ homeostasis, oxidative stress and protein turnover is outlined and how these processes affect cell function and susceptibility to cell death is discussed. Expand
Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage.
  • C. Perier, K. Tieu, +7 authors M. Vila
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
TLDR
A model in which defects of complex I lower the threshold for activation of mitochondrial-dependent apoptosis by Bax, thereby rendering compromised neurons more prone to degenerate is proposed, which may have far-reaching implications for the development of effective neuroprotective therapies for these incurable illnesses. Expand
Mitochondria as a Pharmacological Target
TLDR
This review presents a recent state of knowledge and understanding of the action of various therapeutically applied substances on mitochondria, including antitumor, immunosuppressant, and antiviral drugs, potassium channel openers, sulfonylureas, and anesthetics. Expand
Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.
  • E. Fosslien
  • Biology, Medicine
  • Annals of clinical and laboratory science
  • 2001
TLDR
Different tissues display distinct sensitivities to defective mitochondrial oxidative phosphorylation (OXPHOS), and human tissues can counteract OXPHOS defects by stimulating mitochondrial biosynthesis; however, above a certain threshold the lack of ATP causes cell death. Expand
...
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4
5
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